Senior Clinical and Research Trial Physician - Neurosciences

Job summary

The Department of Neuroscience is part of the network services care group and is one of the largest in the country. It covers southeast London and Kent and encompasses almost all aspects of neurological/ neurosurgical clinical care.

The post-holder will actively support clinical trial recruitment and delivery across Research Delivery Unit (RDU) 1 - Neurosciences, acting as a sub-investigator on a range of trials from phase 1 first in human to phase 3 trials. The post-holder will lead on complex clinical trials (such as CAR-T cell therapy and Advanced Therapy) and they will work closely with multidisciplinary clinical teams, Principal Investigators, academic partners and research delivery staff to promote and enhance research activity within the RDU and department of Neurology.

The post-holder is expected to work in adherence to Good Clinical Practice (GCP), research governance and Trust policies and processes. Additionally, the post-holder is expected to work autonomously, keep meticulous records and possess excellent organisational skills.

In addition to research work, the clinical research fellow may have the opportunity to undertake outpatient clinics at the Parkinson's centre of excellence as well as general neurology clinics. There may be an opportunity to participate in the unit's Neurology teaching program.

Main duties of the job

• Support the timely delivery of clinical trials conducted within RDU 1 - Neurosciences to acceptable medical standards, in line with the requirements of sponsors, ICH GCP, and other appropriate guidelines and regulations.
• Provide medical assessment and cover for selected studies, working alongside the clinical research delivery team in RDU 1.
• Initiate definitive strategies to anticipate and expertly manage medical safety issues, including emergencies.
• Act as Sub-Investigator on designated research studies.
• Be responsible for specific study-related medical decisions as agreed with the Principal Investigator
• Assess participant eligibility against protocol-specific inclusion and exclusion criteria and maintaining up to date screening lists.
• Obtain informed consent in adherence to ICH GCP from study participants.
• Perform clinical assessments, medical histories and physical examinations and prescribing study medication.
• Perform clinical procedures as appropriate to the assigned study (including, but not limited to, clinical examinations or testing, insertion of intravenous lines, assessment of adverse events and management of medical emergencies)
• Evaluate and manage acute, sub-acute and chronic adverse drug reactions and manage acutetoxicological emergencies under the supervision of the consultants in charge.

Please review job description for additional information.

About us

The Trust provides a full range of local and specialist services across its five sites. In June 2026, we launched our new strategy for 2026-31. Our vision is to transform healthcare, and we have agreed six strategic ambitions to help us improve care for patients, and the working lives of our staff.

Our six strategic ambitions are deliveringhigh-quality patient care; creating a great place to work; leading pioneering research, innovation and education; building strong and successful partnerships; providing timely and efficient care; and ensuring long-term financial sustainability.

We have also agreed four new organisational values - Caring, Collaborative, Inclusive, Innovative - and these underpin everything we do, and how our teams interact with the patients under our care.

We are at a pivotal point in our history and we require individuals who are ready to join a highly professional team and make a real, lasting difference to our patients and our people.

King's is committed to delivering Sustainable Healthcare for All via our Green Plan. In line with national Greener NHS ambitions, we have set net zero carbon targets of 2040 for our NHS Carbon Footprint and 2045 for our NHS Carbon Footprint Plus. Everyone's contribution is required in order to meet the goals set out in our Green Plan and we encourage all staff to work responsibly, minimising their contributions to the Trust's carbon emissions, waste and pollution wherever possible.